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BIOREACTORS ARE ACTIVE CULTURE VESSELS ALREADY QUITE GOOD AT MEETING THE NEEDS OF CELLS ... but only while the cells are inside during active operation.

It's the before (seed cells) and after (harvest cells)
that may be of concern.

 

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Bioreactors come in many shapes and sizes. Most are active dedicated culture vessels, although some are passive (operate inside incubators). Directly upgrading a bioreactor is rarely necessary. Rather, it's before and after the bioreactor where cells sometimes need more. 

Bioreactors are different from conventional laboratory appliances used to culture and process cells in passive culture vessels such as plates, flasks, bags, roller bottles etc.  Bioreactors are active culture vessels, which means they are usually closed and dedicated to their one cell population and actively sensing and responding in real-time to cell needs.  Frankly, we were never asked to 'soup up' a bioreactor.

However, they are included in the People-Centric category because of the cells that go into a bioreactor, and the cells that come out.

Cells that seed bioreactors are usually grown and processed in typical People-Centric open CO2 incubators and open hoods.  The consistency and quality of the seed cells can have a significant impact on bioreactor performance.

Cells that are harvested from a bioreactor may also be processed in open People-Centric hoods.  Again, the quality and consistency of the cells may be damaged if the needs of the cells are not considered during processing post-harvest.

Traditionally, the word 'bioreactor' conjures up images of large stainless steel vats.  It is true they were formally used primarily for large scale cell production.  However, there is a recent trend toward downsizing and more functionalizing.  Many new smaller bioreactor systems are being developed, with innovative specialized designs.  The result is an increasing application of bioreactors outside of large scale production, for example, in small scale production and even research.

 

However, sometimes seed & harvest cells need more!

 

Incubator Dependent Bioreactors

Some of the new small bioreactors need to be located inside an incubator.  They use the temperature, CO2, and/or O2 control of the incubator to passively control cell parameters.  Incubators were not designed for cells. They were designed for people.
Sometimes cells in these bioreactors need more >

 

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Optimize conditions while seeding, sampling, and harvesting cells in bioreactors

Integrate any Bioreactor into Cytocentric World

Whether your bioreactor operates inside an incubator or not, integrating it inside an aseptic cell optimized environment will save you time and increase the quality and consistency of your cells.  Chance of contamination goes down.  Seeding cells, sampling cells, harvesting cells all can be done without worry of contamination or suboptimal conditions.  Cleanrooms are no longer required.   The Xvivo System can integrate any bioreactor into a completely cytocentric environment.  Yes, any bioreactor!  Large or small, perfusion or batch, clean-in-place or disposable.  Seed cells upstream, sample cells instream, and harvest cells downstream.  Call for details.  On a smaller scale, especially for those bioreactors that operate inside an incubator, the I-Glove provides the cytocentric advantage immediately!

 

SOMETIMES CELLS NEED MORE... than people!

Have something in mind...ready to upgrade >

 

 

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"The Biospherix unit has been invaluable in enabling us to characterize the way in which human osteoblastic progenitors respond to changes in oxygen tension. Control of oxygen in the environment has proven to be a critical factor in developing effective assays for osteoblastic progenitors and in designing biomaterial surfaces that enhance the survival and proliferation of these progenitors after transplantation."

George F. Muschler, M.D.
CTEC Director

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