Cytocentric Blog

cytocentric visionaries bt02Cytocentric Visionary: Budd Tucker, University of Iowa

Part 2: Modularity is Key to Cell Therapy Process Flexibility

Dr. Budd Tucker is the Stephen A. Wynn Associate Professor of Regenerative Ophthalmology at the Stephen A. Wynn Institute for Vision Research, University of Iowa, where his lab is working on developing cGMP-compliant production of patient-specific retinal cell regenerative medicine using Xvivo Systems from BioSpherix. The transcript was edited for length.

See Part 1 of Alicia Henn’s interview with Dr. Tucker “With iPSC and CRISPR, Leave Nobody Behind, Leave Nobody Blind” here

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cytocentric visionaries bt01Cytocentric Visionary: Budd Tucker, University of Iowa

With iPSC and CRISPR, Leave Nobody Behind, Leave Nobody Blind

Dr. Budd Tucker is the Stephen A. Wynn Associate Professor of Regenerative Ophthalmology at the Stephen A. Wynn Institute for Vision Research, University of Iowa, where his lab is working on developing cGMP-compliant production of patient-specific retinal cell regenerative medicine using Xvivo Systems from BioSpherix. The transcript was edited for length.

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bp top5 of 2017

Top 5 Cytocentric Publications of 2017

With the first approvals of CAR-T, 2017 was a big year for cell-based research and therapies. Some scientific publications stood out from the rest as far as Cytocentric™ advancement. These publications not only encompass cutting-edge cell therapies, but also discoveries that were only made because researchers provided physiologically-relevant conditions for their cells in vitro.

 

#5 Sex differences in the mitochondrial bioenergetics of astrocytes but not microglia at a physiologically relevant brain oxygen tension. Jaber, S.M. and Bordt, E.A, et al. Neurochem Int, (2017).
This group found that in physioxia, astrocytes display different metabolic capacity depending upon whether they were isolated from male or female rats. It is work like this that will help reveal fundamental biological differences that have been hidden by supraphysioxic room air cell culture conditions. See our interview with the young co-first authors, Sausan Jaber and Evan Bordt here. Also, Dr. Bordt has a recent review out on exactly how critical physiologically relevant oxygen is for neuroscience here.

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cytocentric visionaries sjeb01

Do You Know? Oxygen and the Sex of Your Cultured Cells

Sausan Jaber and Evan Bordt are co-first-authors of a recent publication, “Sex differences in the mitochondrial bioenergetics of astrocytes but not microglia at a physiologically relevant brain oxygen tension”, in Neurochemistry International [1]. To control atmospheric conditions for their cells, they used an Xvivo System made by BioSpherix for research.
Sausan Jaber is working on a PhD at the University of Maryland, Baltimore and Evan Bordt recently started a post-doc at Massachusetts General Hospital and Harvard Medical School. Here, Dr. Alicia Henn interviews these young researchers about their recent paper. The conversation was edited for length.

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cytocentric visionaries js1

Cytocentric Visionary: Jeffrey A. Stuart, Brock University

Oxygen: A Big Uncontrolled Variable in Cell Culture

Dr. Jeffrey A. Stuart is an Associate Professor of Biological Sciences at Brock University in St. Catherine’s, Canada. Dr. Alicia Henn interviews him here about his recent publication in BBRC, “Hydrogen peroxide production is affected by oxygen levels in mammalian cell culture. The transcript was edited for length.

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