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ProCO2

Carbon Dioxide Controller

CO₂ Controller for Incubators and Chambers

Fits / controls CO₂ in any
semi-sealable chamber
Control Hypercapnia / Normocapnia:
in vivo and in vitro
Deliver a range of physiologic and
ambient conditions

A VERSATILE CARBON DIOXIDE TOOL
The ProCO₂ P120 is a versatile and compact carbon dioxide controller for carbon dioxide sensitive work. It fits and controls carbon dioxide in any shape or size semi-sealable enclosure and makes it easy to control the carbon dioxide level inside the host chamber. Carbon dioxide is quickly taken to the desired setpoint and held there indefinitely. Disturbances are instantly detected and immediately corrected.

PHYSIOLOGIC OR AMBIENT RANGES
Control setpoint can be anywhere from 0.1-20.0% carbon dioxide for most physiologic concentrations. Alternatively, low level, high resolution setpoints from 10-10,000 PPM can be controlled over ambient range

FULL RANGE PRECISE CONTROL
Control setpoint can be anywhere from 0.1-20.0% carbon dioxide. It senses carbon dioxide inside the chamber and infuses either nitrogen to lower the concentration or carbon dioxide to raise it.

WORKS IN ANY CHAMBER
The ProCO₂ P120 fits and controls carbon dioxide in any semi-sealable enclosure. Whatever size, shape, rigidity, or isolation, most chambers can be fitted in minutes. The ProCO₂ P120 works from outside the host chamber by remotely sensing the CO₂ inside the chamber. It infuses CO₂ gas to raise the carbon dioxide levels, or nitrogen to displace and lower the CO₂ levels.

Handle any CO₂ Sensitive Research Protocol:

...where ambient air carbon dioxide (~350 PPM) is too high or too low, the ProCO₂ P120 can provide any other level you need.

...where ambient atmosphere is not air, the ProCO₂ P120 can restore and maintain air-equivalent carbon dioxide.

...where CO₂ consumptive or generative processes need to be countered, the ProCO₂ P120 can hold CO₂ stable against destabilizing loads.

CONTROL IS EFFICIENT
The ProCO₂ P120 gains feedback from the CO₂ sensor in order to precisely regulate gas infusion according to the setpoint. No gas is ever wasted.

OPERATION IS SIMPLE
CO₂ is quickly taken to the desired setpoint and held there indefinitely. Any disturbances are instantly detected and corrected immediately. Calibration and gas supply must be checked once in a while. Otherwise it's all automatic.

It can work continuously year round or on occasion as needed. No other carbon dioxide tool offers so much value!

It's not expensive and it's available now.
Get More Information...

Accurate, easy, gas efficient CO₂ control

OPERATION

GAS EFFICIENT CO₂ CONTROL

From outside the host chamber, the ProCO₂ P120 works by remotely sensing the carbon dioxide concentration inside the chamber and infusing either nitrogen to lower it or carbon dioxide to raise it.

Installation is easy! Simply insert sensor and nozzle of infusion tube into chamber through any convenient passageway. Doors, windows, sample ports, access ports, holes (built-in or custom-drilled) all work. Just set the ProCO₂P120 on or near the host chamber and plug it in. Hook up the sensor and gas infusion tube and insert both into the chamber. Then hook up the gas supply.

The ProCO₂ P120 works with a variety of BioSpherix SubChambers or other semi-sealed devices and with the ProOx P110 for oxygen and carbon dioxide control. Superior CO₂ control and accuracy are achieved using state of the art dual-beam infrared sensor technology.

Compact, easy to read, easy to use

Front Panel Interface

All controls are located on the front panel of the ProCO₂ P120 with all connections on the back panel. Carbon dioxide concentration at the sensor is displayed continuously in a highly visible green lighted digital readout.

Typical Configuration

INSTALLATION

Set ProCO₂ P120 on or near host chamber and plug it in.
Hook up sensor and gas infusion tube and insert both into chamber.
Hook up gas supply.

Calibration

This eliminates the need for costly third party carbon dioxide analyzers. For easy calibration check, remove sensor from the chamber and check it against room air (0%).

Another option for checking calibration is using the bleed valve on the front panel against a calibration gas.

A manual gas shut off switch allows the user to save gas when the chamber door is open. The alarm which also has a manual switch, sounds when it detects unsafe levels.

Use Any Gas Supply

The ProCO₂ P120 can be used with any gas source. The best supply depends on consumption. Compressed gas is best in low consumption applications. Liquid is recommended for mid-level applications. A generator is best in high consumption applications.

SAVES ON GAS IN THE TANK AND SPACE IN THE INCUBATOR...
Chamber gas consumption varies widely, but in every case the ProCO₂ P120 always and absolutely minimizes consumption. That’s the nature of feedback control, it’s maximally efficient!

Gas costs are reduced to absolute minimum.

PERFORMANCE

NORMOBARIC CARBON DIOXIDE FEEDBACK CONTROL
ProCO₂ P120 works in semi-sealable chambers. It controls chamber CO₂ by forced displacement of gas inside chamber via dilution with either CO₂-rich or CO₂-poor control gas. Pressure inside the chamber stays the same as pressure outside

Dilution is a logarithmic process. The further away from ambient, the slower it goes, but closed-loop control is efficient. By constantly monitoring chamber CO₂, it promptly gets to setpoint. It responds immediately to correct any disturbance. It automatically adjusts to different loads. And in the process, it uses the least amount of gas possible. Day in and day out. Year after year!

HYPERCAPNIA
Hypercapnia is a relative term that means excess concentration of CO₂. The ProCO₂ P120 can create hypercapnia by infusing the CO₂ into the chamber until it reaches the setpoint and holding it there.

NORMOCAPNIA MAINTENANCE
Normocapnia is a relative term that means normal ambient CO₂ concentration. Ambient air usually has very low levels of CO₂, about 350-370 PPM. The ProCO₂ P120 can keep the CO₂ at normal levels for example in an animal chamber where animals are creating CO₂.

TIGHT EFFICIENT CONTROL DISPLAYED BY THE PROCO₂ P120 IN A REAL WORLD SCENARIO

No control yet. Chamber CO₂ is ambient air CO₂ (0%).
Control starts. Control gas is CO₂. Infusion immediately starts to push CO₂ up.
CO₂ is taken to setpoint. How fast depends on infusion rate. Infusion rate is adjustable. The higher the infusion rate, the faster to setpoint (see graph above). Gas consumption in this phase is mostly a function of chamber size.The larger the chamber, the more gas it takes.
Steady-state control at setpoint is established. Infusion of control gas exactly matches chamber leakage to hold CO₂ level constant. Gas consumption here is mostly a function of chamber leakage. The leakier the chamber. The more gas it takes.

Door of chamber is suddenly opened and closed. Steady-state is disrupted. In-rush of air is immediately detected and chamber CO₂ is promptly returned to setpoint. Gas consumption depends on how wide and how long the door was opened. The more it’s disrupted, the more gas it takes to get back to set point.
Door suddenly unlatches. Leakage goes up, but the ProCO₂ P120 compensates and immediately re-establishes steady set point. Gas consumption goes up dramatically, but CO₂ is kept at set point. Consumption increases in proportion to leakage.
Door gets shut tight. Leakage goes back down to normal. The ProCO₂ P120 compensates in opposite direction and re- establishes steady-state at setpoint. Gas consumption goes back down to normal levels, while CO₂ stays put.

"The Information we gain with the Xvivo System is important to our mission of developing therapies to improve patients' lives."

The Wake Forest Institute for Regenerative Medicine Winston-Salem, NC
www.wfirm.org

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